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TivatrainerXfor Iphone, Ipad and MacBook(with M1 chip)

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Check out the I-Manual page for an interactive explanation of the current functions

Drug models available on internet, downloadable to iPhone for off line use, here is how
Updated 29 December 2021

Drug name[author]  Publication  Comments 
Propofol [Marsh]  Br J Anaesthesia 1991;67:41-48  Original diprifusor implementation
weight related 
Propofol [Eleveld 2]  BJA, Vol 120,nr 5, May 2018, 942-959
PK/PD for broad application in anaesthesia and sedation
Covariates: age,weight,gender,length,BMI
for use of propofol only: NO OPIOIDS  
Propofol [Eleveld 2]  BJA, Vol 120,nr 5, May 2018, 942-959
PK/PD for broad application in anaesthesia and sedation
Covariates: age,weight,gender,length,BMI
for use of propofol WITH OPIOIDS
Remifentanil [Eleveld] Anesthesiology 2017; 126:1005-18 Population Pk. Complex modelling using Fat Free Mass, BMI and allometric scaling
Propofol [Cortinez]  British Journal of Anaesthesia 105 (4): 448-56 (2010)  for obese patients. Allometrically scaled to weight 
Remifentanil [Minto]  Anesthesiology 1997;86(1):10-23  Covariates: lbm(James);age;weight;length
interaction with Propofol 
Alfentanil [Maitre]  Anesthesiology; 1987;66;3-12  Covariates: age,weight,gender
interaction with propofol 
Fentanyl [Shafer]  Anesthesiology 1990;73:1091-102  Covariate:weight
interaction with Propofol 
Sufentanil [Bovill]  Anesthesiology 1984:61(5):502-6  Covariate:weight
interaction with Propofol 
Midazolam [Zomordi]  Anesthesiology 1998;89:1418-1429  Covariate: weight
Study in ICU sedation 
Propofol [Schnider]  Anesthesiology; 88,5,1998  Covariates: LBM(James), weight,length,gender,age
fixed keo, Time to Peak Effect patient dependent
implemnted in ETCI Fresenius, Braun
Propofol [Schnider(Alaris)]  Anesthesiology; 88,5,1998  Covariates: LBM(James), weight,length,gender,age
fixed Time to Peak Effect,keo patient dependent
implemented in ETCI Alaris, Arcomed 
Propofol [Absalom/Kenny]  Br J Anaesthesia 2005:95(1):110-13  Peadiatric set: Peadfusor.
Covariates:weight,age
1-15 yr; >5kg 
Tranexamic acid [Grassin-Delyle]  British Journal of Anaesthesia 111(6);916-24(2013) Covariate: allometric weight
Adults cardiac on pump surgery
Dexmedetomidine [Dyck]  Anesthesiology 78:821-828; 1993  Covariate: length
used for Target Controlled Infusion 
Propofol [Eleveld]  Anesthesia Analgesia 2014 vol 118  General purpose Pk model, Patient
Covariate age, weight, gender.
Unified model for peadiatric, normal adult, elderly and obese (see Road map)
Propofol [Marsh, Thomson]  Pk: Br J Anaesthesia 1991;67:41-48 Anaesthesia
Pd: 2014 vol. 69 (5) pp. 420-428
Covariate: weight
Intermediate keo(0.6/min)  
Propofol[White/Kenny] Clin Pharmacokinet 2008; 47 (2): 119-127 Marsh model with age and gender as covariable.
Propofol[Marsh(Short keo)] Pk: Br J Anaesthesia 1991;67:41-48 keo adjusted to yield time to peak effect(TPE) of 1.6 min
used for effect site control with Propofol[Marsh]
in Fresenius TCI pump
Dexmedetomidine[Hannivoort] Anesthesiology, 123(2), 357–367 ;2015;British Journal of Anaesthesia, 119 (2): 200–10 (2017) Pk used for TCI, weight allometric adjusted. Full Pd implemented (Hr,MAP,BIS, MOAAS)
Lidocaine[Kuipers] Anesthesiology,2001 94(4), 566–573. Model C used (see publication)
Sufentanil[Greeley] Anesth Analg 1987;66:1067-72 neonates, paediatric Pk
Paracetamol[Wuerthwein] Eur J Clin Pharmacol[2005] 60:883-888 Time to peak effect: 1 hr based on Eur J Clin Pharmacol1991; 40: 241–247
Paracetamol[Wang] Th Journal of Clinical Pharmacology 54(6)619-629 Population analysis (NONMEM) on 220 subjects: neonates infants children and adults
Time to peak effect: 1 hr based on Eur J Clin Pharmacol1991; 40: 241–247
Ketamine S+[Geisslinger] Pharmacokinetics of ketamine enantiomers. British Journal of Anaesthesia,1995 75(4), 506–507. Weight as coparameter
Ketamine Racemic[Clements] Clements JA, Nimmo WS. Pharmacokinetics and analgesic effect of ketamine in man. Br J Anaesth 1981; 53: 27 – 30 Weight as coparameter
Racemic Ketamine. Tested for low dose infusions in neuropsychological testing in healthy subjects (Predictive performance of the Domino, Hijazi, and Clements models during low-dose target-controlled ketamine infusions in healthy volunteers British Journal of Anaesthesia 98 (5): 615–23 (2007)
Ketamine S+[White] Pharmacokinetics of S(+) ketamine derived from target controlled infusion. British Journal of Anaesthesia(2006), 96(3), 330–334. http://doi.org/10.1093/bja/aei316 weight as coparameter
Morphine[Sarton] Adv. Exp.Medic.Biology 2003 Sex differences in keo
Sufentanil[Gepts] Anesthesiology 1995;83:1194-204 WARNING: NO relation with weight length or age !!
research patients: weight between 47 and 94 kg age between 17 and 68 yr length between 159 and 182 cm
DO NOT USE IN PEDIATRIC (too low possible weight(1kg!) in ALARIS and MINDRAY TCI pumps!!)